How i disable mod security for a domain or dir??

[kilburn]

It didn't work in the roundcube case because it is running under the panel's VirtualHost which prevents overriding any options through .htaccess:
/etc/apache2/sites-enabled/00_master.conf

Code:

...
    <Directory /var/www/ispcp/gui>
        Options -Indexes Includes FollowSymLinks MultiViews
        AllowOverride None
...

Thus, you can either:

1. 1) Change to AllowOverride All so the .htaccess file becomes actually effective.
2. 2) Add the <IfModule mod_security...</IfModule> block into the above <Directory /var/www/ispcp/gui>...</Directory> block.